Lediga jobb Acrivon AB i Lund

Responsibilities
Perform research to help elucidate drug mechanism-of-action and resistance mechanisms through experimental design, execution, and data interpretation.
Perform research to design, screen and analyze data to evaluate drug candidates in our early discovery pipeline.
Develop novel mechanism-of-action cell-based models that closely mimic human cancer to enable biomarker discovery, answer mechanistic questions and validate biomarkers for therapeutic targets.
Participate in analysis and evaluation of large phospho-proteomic data sets from drug profiling studies of both cell lines and tissue samples through signal transduction pathway-based analyses.
Contribute as a member of a diverse and motivated team of researchers across Oncology disciplines and key internal and external collaborators.
Read and critically evaluate literature to keep abreast of scientific and technological advances.
Lead or contribute to scientific publications.
Qualifications
· PhD in cell biology, cancer biology or other related scientific discipline with at least 5 years of relevant experience in academia or industry.
· Demonstrated expertise in cancer biology, signal transduction, oncogenic signaling pathways, and/or translational biomarker research required.
· Excellent written and interpersonal communication skills with the ability to interact effectively with internal and external colleagues are required.
· Ability to troubleshoot effectively and constructively implement solutions within the broader teams.
· Proven track record of quality research and deep scientific knowledge as evidenced by high impact, peer reviewed publications highly preferred.
Knowledge and hands-on experience in several of the following areas are highly desirable:
· Molecular and Cellular Biology: Western blotting, ELISA, immunofluorescence
· Expertise related to DNA damage response (DDR) signaling, cell cycle regulation and/or DNA replication biology.
· Cell-based assays: tissue culture, cell proliferation and viability assays, reporter assays, flow cytometry and cell cycle analysis, transfection, assays examining DNA damage and DNA replication stress response pathways.
· Demonstrated expertise in development/optimization of in vitro/ex vivo
· Experience in microscopy.
· Proficiency in data collection/analysis/documentation of all study results in the form of electronic lab notebook reports. Visa mindre

Position Overview:

Acrivon Therapeutics/AB is seeking a highly motivated Research Associate to join our Proteomic Discovery team at Acrivon AB, our Sweden site located in Medicon Village, Lund. The successful candidate will be engaged in research of therapeutic agents and biomarkers for our portfolio of drug development programs in oncology. The candidate will support, perform and develop assays for drug profiling, using proteomics and phosphoproteomics in cell lines, animal models and patient samples.


Duties & Responsibilities
Support all ongoing research projects with cell culture, protein assays, drug MoA assays, and proteomic profiling
Develop and perform robust cell-based assays for drug profiling
Support general lab duties, organization and activities
Comply with all applicable regulations; Ensure that work performed in area of responsibility is conducted in a safe and compliant manner; Maintain proper records in accordance with SOPs and policies.
Prepare clear technical reports and communicate results and plans on a regular basis

Requirements:
M.S. in Biological Sciences or in a related discipline
2-3 years of laboratory experience in academic research or in industry, experience in cancer research is highly desirable
Broad molecular biology laboratory skills including cell-based assays, microscopy, Western Blot, PCR, etc.
Knowledge and experience in working with cancer cell lines and models, as well as signaling pathways in tumor biology
Experience in drug development and proteomic profiling in cancer models
Excellent communication, organizational skills and working knowledge of Microsoft Office
Ability to work independently and as a team member in a fast-paced environment
Fluent in English



About Acrivon Therapeutics:
Acrivon Therapeutics is a personalized oncology start-up company specialized in accelerated drug development using a unique, proprietary proteomics-based patient selection platform, called AP3. Their unbiased method is widely applicable across the majority of cancers, and specifically applied to oncology drugs to enable the development in clinical trials using a quantitative predictive and pharmacodynamic protein biomarker signature. The experienced, founding team has pioneered and proven all the required technologies and platforms. Visa mindre