Lediga jobb Saromics Biostructures AB i Lund

SARomics Biostructures is one of the fast-growing biotech companies in Lund. We strive to accelerate drug discovery through structural insight. Our international team of over 25 researchers cover the following fields of expertise: protein engineering, expression, purification and characterization, biophysical screening, protein NMR analysis, protein X-ray crystallography and computational chemistry. SARomics has built a global reputation for its structural biology platform and its structure-based drug design skills and is currently supporting mainly international clients in the pursuit of their drug discovery objectives. In parallel, the company is pursuing a number of internal drug discovery projects aiming to discover leads for new medicines.
We are currently seeking a skilled and highly motivated research scientists to expand and strengthen our team, which work on protein production and crystallization. The candidate can either have strong skills in protein expression and purification or have some competence in both protein production and crystallization. While not necessary, having competences in both areas will be considered as an advantage. The position involves working closely with an experienced team of interdisciplinary researchers and to regularly present findings to the project team, senior management, and clients
The ideal candidate will be self-driven, resourceful, organized, focused, service-minded, and enjoy working in a dynamic and fast-paced team environment. The candidate should have a strong desire to learn new techniques, have the ability to incorporate new methodologies into their work and to carry out innovative and high-quality research to answer challenging questions in structural biology.
Successful candidates’ requirement:
Ph.D. in biochemistry, biotechnology, molecular biology, structural biology, or related fields
Experience from independent planning and performing of experiments and analyzing and drawing conclusions from generated data in a scientific research setting
An understanding of protein structure and biophysical properties
Have excellent analytical, organizational and communication skills - fluency in English (spoken and written) is expected
Ability and desire to work in a fast-paced, dynamic environment to ensure timely progress in customers projects
Legally authorized to work in Sweden



Required knowledge, skills and abilities:
For protein production
Expertise in recombinant protein expression in E. coli, insect and/or mammalian cells
Expertise in recombinant protein purification using techniques such as affinity chromatography, IMAC,SEC, IEX, etc.
Working knowledge and practical experience with ÄKTA systems will be highly advantageous
Expertise with general protein characterization techniques such as SDS-PAGE gel, Western blot, thermal shift assays, etc.



For crystallization
Experience of protein crystallization of a “wide variety of proteins”
Experience in all steps of structure determination (including data collection to refinement)
An ideal candidate will also have had experience with structure-based design and drug discovery projects



The successful candidate will get the opportunity:
to join an energetic and enthusiastic international team with a focus on scientific excellence and teamwork
to evolve in a highly multidisciplinary environment and thus develop new competencies outside their core expertise
to accelerate discovery through structural insight



Explore our website to find out what it is like to work at SARomics Biostructures: https://www.saromics.com
For specific questions regarding the position please call Nadia Rose +46 46 26 10 474.
If you are interested in a career with us, please forward a CV/resume and a cover letter to [email protected] and label your message with subject “SBX Career” no later than February 18, 2024.
We will interview candidates continuously and would therefore like to receive your application as soon as possible!
The application should be in English. Visa mindre

SARomics Biostructures is one of the fast-growing biotech companies in Lund. We strive to accelerate drug discovery through structural insight. Our international team of over 25 researchers covers the following fields of expertise: protein engineering, production and characterization, biophysical screening, NMR spectroscopy, structural biology and computational chemistry. SARomics has attracted significant funding for its research programs and is currently involved in several international research initiatives aiming to discover leads for new medicines. In parallel the company has built a global reputation for its structural biology platform and its structure-based drug design skills. SARomics is currently supporting mainly international clients in the pursuit of their drug discovery objectives. We are now seeking a skilled and highly motivated research scientist to expand and strengthen our protein production teams.
The successful candidate will:
Participate in the development of innovative approaches for production of high-quality purified proteins
Work closely with scientific team of interdisciplinary researchers to ensure timely progress in customers projects
Provide hands-on experience in clone design, protein expression and purification to support biophysical and structural efforts
Characterize protein samples before crystallization trials using biophysical methods
Analyze, document and report experimental data
Work closely with an experienced team of interdisciplinary researchers and have regular opportunities to present findings to the project team, senior management and clients



Required knowledge, skills and abilities:
The ideal candidate will be self-driven, resourceful, organized, focused, service-minded, and enjoy working in a dynamic team environment driven to deliver quality proteins to enable drug discovery. The candidate should have a strong desire to learn new techniques, have the ability to incorporate new methodologies into their work and to carry out innovative and high-quality research to answer challenging questions in structural biology. Specific requirements are:
M.Sc./Ph.D. in biochemistry, biotechnology, molecular biology, structural biology or related fields along with hands-on experience in protein purification
Expertise in recombinant protein expression in E. coli, insect and/or mammalian cells
Expertise in purification of recombinant proteins using techniques such as affinity chromatography, IMAC, SEC, IEX, etc.
Working knowledge and practical experience with ÄKTA systems will be highly advantageous
Expertise with general protein characterization techniques such as SDS-PAGE gel, Western blot, thermal shift assays, …
Ability and desire to work in a fast-paced, dynamic environment
Ability to work well independently and as part of a team
Excellent analytical, organizational and communication skills are essential - fluency in English (spoken and written) is expected
Legally authorized to work in Sweden



The candidate will get the opportunity:
to join an energetic and enthusiastic international team with a focus on scientific excellence and teamwork
to evolve in a highly multidisciplinary environment and thus develop new competencies outside their core expertise
to accelerate discovery through structural insight





Explore our website to find out what it is like to work at SARomics Biostructures: https://www.saromics.com
For specific questions regarding the position please call Nadia Rose +46 46 26 10 474.
If you are interested in a career with us, please forward a CV/resume and a cover letter to [email protected] and label your message with subject “SBX Career” no later than March 3, 2023. However, we will interview candidates continuously and welcome your application today!
The application should be in English. Visa mindre

SARomics Biostructures is one of the fast-growing biotech companies in Lund. We strive to accelerate drug discovery through structural insight. Our international team of over 25 researchers cover the following fields of expertise: protein engineering, production and characterization, biophysical screening, protein NMR analysis, protein X-ray crystallography and computational chemistry. SARomics has built a global reputation for its structural biology platform and its structure-based drug design skills and is currently supporting mainly international clients in the pursuit of their drug discovery objectives. In parallel, the company is pursuing a number of internal drug discovery projects aiming to discover leads for new medicines.
We are currently seeking several skilled and highly motivated research scientists to expand and strengthen our teams, which work on protein production and crystallization. The candidates can either have strong skills in protein production and/or crystallization but some competence in both areas, while not necessary, will be an advantage.
The ideal candidate will be self-driven, resourceful, organized, focused, service-minded, and enjoy working in a dynamic and fast-paced team environment. The candidate should have a strong desire to learn new techniques, have the ability to incorporate new methodologies into their work and to carry out innovative and high-quality research to answer challenging questions in structural biology.
Successful candidates’ requirement:
Ph.D. in biochemistry, biotechnology, molecular biology, structural biology, or related fields
Work closely with an experienced team of interdisciplinary researchers and have regular opportunities to present findings to the project team, senior management, and clients
Have excellent analytical, organizational and communication skills - fluency in English (spoken and written) is expected
Ability and desire to work in a fast-paced, dynamic environment to ensure timely progress in customers projects
Analyze, document, and report experimental data
Legally authorized to work in Sweden



Required knowledge, skills and abilities:
Experience of protein crystallization of a “wide variety of proteins”
Experience in all steps of structure determination (including data collection to refinement)
An ideal candidate will also have had experience with structure-based design and drug discovery projects.



The successful candidate will get the opportunity:
to join an energetic and enthusiastic international team with a focus on scientific excellence and teamwork
to evolve in a highly multidisciplinary environment and thus develop new competencies outside their core expertise
to accelerate discovery through structural insight



Explore our website to find out what it is like to work at SARomics Biostructures: https://www.saromics.com
For specific questions regarding the position please call Martin Welin +46 46 26 10 474.
If you are interested in a career with us, please forward a CV/resume and a cover letter to [email protected] and label your message with subject “SBX Career” no later than August 6, 2023. We will interview candidates continuously and would therefore like to receive your application as soon as possible!
The application should be in English. Visa mindre

SARomics Biostructures is one of the fast-growing biotech companies in Lund. SARomics has attracted significant funding for its research programs and is currently involved in several international research initiatives aiming to discover leads for new medicines. In parallel the company has built a global reputation for its structural biology platform and its structure-based drug design skills and is currently supporting clients in Asia, Australia, Europe and North America to pursue their drug discovery objectives. We are now seeking an experienced protein crystallographer to expand and strengthen our structural biology team.
The successful candidate will:
Set up crystallization trials and optimize protein crystals
Collect synchrotron X-ray data and perform structure determination independently
Characterize protein samples before crystallization trials using biophysical methods
Analyze, document and present/report experimental data

Qualifications
The successful candidate is a skilled, organized, service-minded life-science professional with a positive attitude, who enjoys laboratory-based projects in a fast-paced, team environment. The candidate should have the ability to carry out innovative and high quality research to answer challenging questions in structural biology.
Minimal requirements:
Ph.D. in structural biology or equivalent
Experience of protein crystallization of a wide variety of proteins
Strong experience in all steps of structure determination (including data collection to refinement)
An ideal candidate will also have had experience with structure-based design and drug discovery projects
Excellent analytical, organizational and communication skills are essential

You will get:
An opportunity to join an energetic and enthusiastic team with a focus on scientific excellence and teamwork
An opportunity to evolve in a highly multidisciplinary environment and thus develop new competencies outside your core expertise
An opportunity to accelerate discovery through structural insight

Explore our website to find out what it is like to work at SARomics Biostructures: http://www.saromics.com Visa mindre

SARomics Biostructures is one of the small fast-growing biotech companies in Lund. The company has attracted significant funding for its research programs and is currently involved in several international research initiatives aiming to discover leads for new medicines. In parallel the company has built a global reputation for its structural biology platform and its structure-based drug design skills and is currently supporting clients in Asia, Australia, Europe and North America to pursue their drug discovery objectives. We plan to strengthen our team with a Lab technician to assist our protein production unit with protein expression, purification and characterization.

The successful candidate will:
- Participate in the normal day-to-day running of the lab.
- Express proteins in E. coli and insect cells
- Operate and maintain specific equipment for protein expression and purification
- Perform certain administrative functions like ordering of consumables and chemicals

Your qualifications:
The successful candidate is a skilled, organized, service-minded life-science enthusiast with a positive attitude, who enjoys laboratory-based work in a fast-paced team environment. The candidate should be eager to learn and take instructions but also have the potential to work independently.

Minimal requirements:
- University degree in biochemistry, biomedicine, biotechnology or another relevant
subject
- MSc in the relevant area is a plus but is not mandatory
- Documented exposure to a protein chemistry laboratory
- Experience with protein expression in E. coli and/or insect cells
- Ability to carry out all laboratory operations in a safe and effective manner and to maintain a clean and orderly laboratory environment
- A strong interest in learning and implementing developed techniques in protein chemistry

You will get:
- An opportunity to join an energetic and enthusiastic team with a focus on scientific excellence and teamwork
- An opportunity to evolve in a highly multidisciplinary environment and thus develop new competencies outside your core expertise
- An opportunity to accelerate discovery through structural insight

For more information about SARomics Biostructures: http://www.saromics.com
Contact: Dr. Raymond Kimbung, +46 76 8585709, [email protected].

If you are interested in a career with us, please forward a CV/resume and a cover letter
to [email protected] with subject "SBX Career" no later than December 1, 2019. Visa mindre

SARomics Biostructures, Lund, Sweden and the Computational Receptor Biology group, Department of Drug Design and Pharmacology, University of Copenhagen wishes to employ a joint PhD Fellow in molecular modelling. The employment at SARomics Biostructures starts November 4th 2019. SARomics aim is to offer the successful applicant full time employment after the project is finished.


SARomics Biostructures is one of the small fast-growing biotech companies in Lund. SARomics has attracted significant funding for its research programs and is currently involved in several international research initiatives aiming to discover leads for new medicines. In parallel the company has built a global reputation for its structural biology platform and its structure-based drug design skills and is currently supporting clients in Asia, Australia, Europe and North America to pursue their drug discovery objectives.


The Computational Receptor Biology group conducts bioinformatics, scientific data analysis and computational drug design, tightly integrated with leading chemists and pharmacologists, and structure-function studies of G protein-coupled receptors (GPCRs) – one of the largest drug target families.


Project
The PhD student will obtain ample scientific, business and transferrable skills at excellent research environments meriting him/her for an international academic or industrial career. The project will focus on structure based design of ligands with functional selectivity at the 5-HT2A receptor. The ultimate scientific goal is to gain molecular understanding and improve selectivity in treatments of CNS-related disorders. This will be done with a particular focus on the serotonin 5-HT2A receptor – the primary target for many pharmaceuticals and hallucinogens. The PhD fellow will design and prepare ligands for the receptor, generate and cross-interpret pharmacology and crystallographic data, and construct computational mechanistic models and databases that can explain and guide further experiments. This is fundamental to understand the biological and therapeutic effects, and to develop safer drugs.
Qualification requirements
Mandatory requirements
1. A MSc in in computational chemistry, bioinformatics or similar topic
2. Experience of data analysis related to G protein-coupled receptors
3. Demonstrated ability to independently learn new concepts and solve biological problems
4. Fluency in English and experience in writing scientific texts
5. The candidate must have less than 4 years of research experience and must not have resided or carried out his/her main activity in Sweden for more than 12 months during the last 3 years immediately prior to the recruitment
Additional meriting qualifications
Experience of, and skills in:
• Analysis of molecular structures and interactions
• The Schrödinger Drug Discovery Suite, Desmond and PyMOL
• Shell scripting, programming in Python or other languages, and web development
Key criteria for the assessment of applicants
• Professional qualifications relevant to the project
• Relevant work experience
• Publications
• Other professional activities
• Language skills
• Good interpersonal skills


Application
The application, in English, must include a cover letter and the following appendices:
Appendix 1: curriculum vitae with documentation of education.
Appendix 2: a complete list of publications and list of submitted appendices.
Appendix 3: documentation of additional research qualifications. Visa mindre